Synthetic oligonucleotides such as small interfering RNAs (siRNAs) and anti-sense oligonucleotides (ASOs) can target specific genes and regulate their expression. These therapeutic agents can be designed to target aberrantly expressed genes in a wide range of disease conditions. The new miRNAscope™ assay can visualize and monitor the delivery and biodistribution of these synthetic RNA molecules to access the specificity and efficacy of these therapies.


siRNAs and ASOs can be designed to selectively target oncogenes relevant to specific malignancies and downregulate their expression to control tumor growth.


siRNAs and ASOs are highly promising tools for the clinical treatment of acute brain injury, neurodegenerative disorders and can potentially treat previously inaccessible drug targets implicated in neuromuscular and neurodegenerative disorders.


siRNAs and ASOs can be used to target differentially expressed genes in patients with auto-immune disorders and mitigate disease progression.


Figure 1. The targeting siRNA was detected using the siRNA probe in the siRNA-treated mouse liver tissue samples and not in the vehicle tissue samples using the miRNAscope assay, indicating successful delivery of the siRNA-based therapy. Expression of target mRNA was detected using the RNAscope assay and appeared significantly reduced in the siRNA-treated tissue compared to vehicle-treated tissue suggesting successful knock-down of the target mRNA expression with the siRNA-based therapy.

Recorded Webinar

2020 July 28 - miRNAscope Launch Webinar: Visualize ASO, miRNA, and siRNA Detections with Spatial Resolution using the New miRNAscope™ Assay

Get a deeper understanding of gene expression patterns by using assays that retain spatial organization at single cell resolution! Come learn about the new robust RNA in situ hybridization assay that enables the detection of ASOs, miRNAs, siRNAs, and other smaller RNAs (16-50nt) with spatial and morphological context at single cell resolution.

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Professional Assay Services

  • Unparalleled expertise in RNAscope and BaseScope ISH
  • High capacity and high throughput, delivering more than 10,000 slides per year
  • Supporting dozens of cell and gene therapy companies for research studies enabling pre-IND submission
  • Team of specialists perform quantitative image analysis using HALO™ Software (Indica Labs)
  • Board-certified pathologist review
  • Actionable results delivered in weeks rather than months
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