JAK/STAT Signaling Pathways of Cellular Metabolism
RNAscope™ Applications
JAK/STAT Signaling Pathway
Pathway information and image are provided courtesy of R&D Systems, a Bio-Techne Brand. To access the larger and interactive version of the pathway image visit their website.
The Janus family of tyrosine kinases (JAK) and the signal transducer and activator of transcription (STAT) family is a major signaling pathway involved in cellular metabolism. The JAK/STAT signaling pathway is also involved in several cellular processes, such as proliferation, apoptosis, differentiation and migration. Additionally, dysregulation of the JAK/STAT signaling pathway is linked with a wide range of leukemias, lymphomas, head & neck cancers, melanomas and breast cancers. STAT proteins are activated by cytokines and other receptor kinases, including EGFR, FGFR, CSF1R, PDGFR and other G-protein coupled receptors. Transcription factor and receptor are often expressed at very low levels and therefore development of highly sensitive antibody has been difficult. The ultra-high sensitivity and specificity of the RNAscope™ assay provides an alternative robust detection method of these hard to detect mRNA targets.
(click on gene name to access corresponding RNAscope™ probes)
** If your gene of interest is not listed or is listed above but there is no catalog probe targeting your species of choice, ACD can design and manufacture new probes in 2 weeks.
