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RNAscope® Technology for Diagnostics

Advanced Cell Diagnostics, inventors of the innovative RNAscope® ISH Technology have over 13,000+ RNA probes, designed and ready to use, available for most research areas and applications. RNAscope ®  in situ hybridization technology with its proprietary double Z probe design and reagents enable reliable detection of RNA biomarkers at a single molecule sensitivity within morphological context for FFPE tissues. With 40+ issued and pending patents, over 800 publications and customers in many diagnostic, pharma and academic fields, RNAscope® technology is primed for adoption by the clinical and companion diagnostic community.

RNAscope® ISH for Diagnostics

Advanced Cell Diagnostics have partnered with Leica Biosystems to develop the fully automated RNAscope® ISH technology, available for diagnostic use. The RNAscope® ISH Technology has been optimized for diagnostic and clinical use on the Bond III Advanced Staining Clinical Platform. This will be marketed, sold and supported by Leica Biosystems.

There are currently 5 ASR probes available: targeted for Albumin, CMV, EBV, Napsin-A and TTF-1, covering a number of clinical disease states, as well as control probes: PPIB (Positive) and dapB (negative).

Ordering Information

Product Code

Product Name




RNA probes


CMV Probe

14 mL


Order via Leica


EBV Probe

14 mL


Order via Leica


Albumin Probe

14 mL


Order via Leica


TTF-1 Probe

14 mL


Order via Leica


Napsin A Probe

14 mL


Order via Leica

ISH Control Probes


PPIB (Positive Control)

14 mL


Order via Leica


dapB (Negative Control)

14 mL


Order via Leica

Details and ordering information are available via Leica Biosystems directly, however, please find the informational brochures below:


Leica Bond III ISH and IHC stainer and ACD's RNAscope

Download Brochure


Leica Bond III and ACD RNAscope ISH Chromogenic Probes

Download Flyer

Academic, pharmaceutical and biotechnology customers will still have access to our research use (RUO) RNAscope and BaseScope probes on the Leica Bond Rx System and the Ventana Medical Systems Discovery Ultra and XT Platforms (Automated Advanced Staining Platforms), which will continue to expand into new research areas.

Partnership with Leica Biosystems

Take a look at our short video, describing our partnership and continued progress to advance clinical diagnostics via innovative technologies including RNA ISH.

Watch video

The ACD ASR Chromogenic ISH probes have been developed in partnership by both ACD and Leica Biosystems to be a fully-automated, plug and play RNA ISH that fits seamlessly with existing clinical laboratory equipment and workflows. The clinically proven standard protocol on the Bond III provides superior accuracy, reproducibility and reliability. The established chromogenic detection allows for standard bright-field review and analysis as preferred by pathologists, accustomed to reviewing IHC.

Contact Us

Complete one of the two forms below and we will get back to you.

Advanced Cell Diagnostics

Our new headquarters office starting May 2016:

7707 Gateway Blvd.  
Newark, CA 94560
Toll Free: 1 (877) 576-3636
Phone: (510) 576-8800
Fax: (510) 576-8798



19 Barton Lane  
Abingdon Science Park
OX14 3NB
United Kingdom
Phone 2: +44 1235 529449
Fax: +44 1235 533420



Advanced Cell Diagnostics China

Building 15, No. 26 Xihuan South Road
Beijing Economic-Technological Development Area
Beijing, China, Zip code: 100176

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