Researchers in the spotlight

Learn from other researchers how RNAscope® technology helps them to advance their research in a unique way by adding morphological context to RNA expression analysis.

Interview with Dr. Patricia Pesavento

Insights into viral pathogenesis.

Determination of causation by highly sensitive and specific viral RNA detection and localization with RNAscope® ISH.

“A method as sensitive as RNAscope assay with spatial resolution is absolutely irreplaceable for our confidence in determining viral contribution to a disease.”

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Interview with Dr. Ann-Marie Baker

Characterizing LGR5 stem cells in colorectal adenomas and carcinomas.

Overcoming the limitations of antibody-based detection methods.

“Using the RNAscope assay probe against LGR5 mRNA has allowed us to study the localization of LGR5 expression without relying on an antibody””

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Interview with Dr. Rohit Mehra

Realizing the potential of long noncoding RNA (lncRNA) as a cancer biomarker.

From NGS discovery to validation with RNA in situ Hybridization.

“We found RNAscope technology fast and easy to use, this technology also allows us to directly visualize gene expression in the target tissue of interest ....Also, only one 4 micron FFPE section is sufficient to give us all this information.”

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Interview with Dr. Nallasivam Palanisamy

Development of Prostate Cancer Personalized Medicine.

Advancing analysis of prostate tumor molecular heterogeneity by combined immunohistochemistry and novel RNA in situ hybridization.

“Given the unique probe design and detection chemistry of the RNAscope method, we were able to get results with high specificity and sensitivity for many probes that we have used in my laboratory. To date we don’t have any comparable technology for the reliable detection of RNA in FFPE tissues other than RNAscope.”

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Interview with Dr. Alexy Pronin

Exploring GPCR expression in the eye.

From discovery with NGS to spatial and quantitative expression confirmation with RNAscope® technology.

“Because RNAscope can detect expression of multiple genes in parallel, it can tell us whether those genes discovered through RT-PCR are co-expressed in the same cell or not – information that is very valuable and hard to obtain by other means.”

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Interview with Dr. Sarah Getu and Saskia Smits

Detecting a Novel Circovirus in Foxes with Meningoencephalitis - How custom RNAscope® assay probes are enhancing viral understanding

The burden of infectious diseases on human health worldwide has markedly increased over the past few decades, most of these emerging events are caused by viruses originating from the animal world. Understanding the roots of viral behavior in animal hosts is therefore vital and this is a primary focus of Sarah Getu’s and Saskia Smits’s work at the Department of Viroscience, Erasmus MC. In this interview, they explain how the creation of a custom RNAscope® in situ hybridization (ISH) probe allowed them to localize a newly discovered circovirus to neurologic lesions in foxes, providing valuable information to support causation.

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