Neuronal Cell Types

Detection, characterization and (co-) localization of neuronal cell types and subcellular target localization

The RNAscope® assay can be used for the visualization of multiple target co-expression patterns or the co-expression of the target(s) of interest with desired cell type markers that characterize particular types of neurons or glia. Commonly used cell type markers to distinguish neuronal and glial target expression patterns include Rbfox3, Aif1, and Gfap for the detection of neurons, microglia and astrocytes, respectively. The striatum harbors two distinct neuronal populations that either express Dopamine Receptor D1 (Drd1) – the striatonigral pathway – or Dopamine Receptor D2 (Drd2) - the striatopallidal pathway. These different neuronal cell types can be accurately detected and visualized using the RNAscope® technology. Images for the detection of these different cell type markers can be found in our image gallery.

Download scientific poster “Highly sensitive detection of RNA in mouse central and peripheral nervous system using the RNAscope® ISH Technology

Application review

Learn more in our RNAscope® Neuroscience Application Review - Cellular localization of RNA expression in central and peripheral nervous system using RNAscope® Technology.

Cellular localization of RNA expression in central and peripheral nervous system using RNAscope® Technology

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Neuroscience Gene List

(click on gene name to access corresponding RNAscope® probes)

 

 

 

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