Expert ISH and Image Analysis Services

Professional Assay Services (PAS) provides GCLP-compliant RNAscope, BaseScope™, miRNAscope™ in situ hybridization (ISH) assay services to support clinical and pre-clinical studies for our academic and biopharma partners. We provide end-to-end solutions from sample procurement to ISH staining to image analysis and reporting.  Researchers who partner with Professional Assay Services will receive access to the most specialized and technically experienced RNAscope services of any CRO, provided by an expert multi-disciplinary team that includes PhD scientists and MDs, who serve our clients as technical experts, image analysis specialists and board-certified pathologists, spanning a broad array of scientific disciplines. With direct access to the developers of the technology, the PAS team provides unparalleled expertise in Bio-Techne's ISH platforms and delivers fast, high-quality data designed to meet your study objectives and timelines.


Power Your Next Breakthrough from Target Validation to Clinical Development with RNAscope™ Professional Highlights Assay Services

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Why Choose PAS as your ISH and Multiomic service provider?

  • A decade of experience as a service provider, delivering 15,000+ stained slides per year
  • An established history of servicing 28 of the 30 global pharmaceutical companies as well as dozens of cell and gene therapy biotech companies
  • Ph.D. level scientists and MD pathologists who are specialized experts and provide scientific consultation for study design and data interpretation

What We Offer: Tissue-Based Expression Analysis

  • Target validation. Screen and validate candidate targets by assessing target expression levels in drug-treated versus naïve samples or disease vs normal tissues
  • Biomarker assay development. Evaluate candidate biomarker expression and establish assay performance and dynamic range using bioanalytical method validation guidelines
  • AAV biodistribution. Profile the spatial distribution of AAV vector together with genetically modified transgenes  to assess biodistribution and safety
  • CAR/TCR biodistribution and function. Visualize the biodistribution of CAR T or TCR T cells within the tumor microenvironment and assess functionality with co-detection of immune cell markers and/or markers of activation
  • Safety/toxicology tissue screening. Single-molecule detection for high sensitivity screening of normal tissues for pre-clinical ADME and safety assessment
  • CDx assay development. Partner with ACD to support the assay prototype development, proof of concept and validation steps of your RNAscope CDx assay



PAS Brochure

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Advanced Cell Diagnostics

Our new headquarters office starting May 2016:

7707 Gateway Blvd.  
Newark, CA 94560
Toll Free: 1 (877) 576-3636
Phone: (510) 576-8800
Fax: (510) 576-8798



19 Barton Lane  
Abingdon Science Park
OX14 3NB
United Kingdom
Phone 2: +44 1235 529449
Fax: +44 1235 533420


Advanced Cell Diagnostics China

20F, Tower 3,
Raffles City Changning Office,
1193 Changning Road, Shanghai 200051


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