Target probe panels for anatomic pathology

With our wide portfolio of ready-to-use probes, ACD provides a broad range of high-quality RNAscope probes for your RNA ISH needs in Anatomical Pathology. We have categorized the key RNAscope probes into thirteen Anatomical Pathology panels, based upon most common tumor, tissue and infectious disease types. Each panel includes RNAscope probes designed to enhance assessment and characterization of target markers in the organ-specific disease states. The Anatomical Pathology panels provide labs with the opportunity to add new markers to complement and add additional confirmation to their traditional IHC panels. 

Why choose RNAscope® ISH for your panels?

  • Unparalleled sensitivity and specificity - Detect any marker of interest to complement your IHC or DNA ISH, with consistently reliable results

  • Surpass traditional IHC challenges - Easy validation, omit issues with high background, low signal or suboptimal antibodies

  • Choose your platform - Optimize your workflow, RNAscope® ISH probes are available and ready-to-use in both manual and automated formats. RNAscope probes have been developed for full automation on the Leica BOND and Ventana Discovery platforms

  • Intuitive protocol, implemented seamlessly into your workflow - The RNAscope® ISH protocol is easy to follow, similar in many steps to IHC and can be transferred to your established staining platform* with ease

*for Leica BOND and Ventana Discovery platforms

Ease of Data Analysis

RNAscope® ISH is easy to interpret and quantify, with a single punctate dot representing 1 RNA molecule, unlike scoring with IHC. In this Non-Small Cell Lung Cancer (NSCLC) FFPE sample, each single dot represents a PDL1 RNA molecule. Tumor is highly heterogeneous, with low, medium and high regions of expression identified.

List of Panel

Breast Pathology

Marker Probe Name
HER2 (ERBB2) Hs-ERBB2
ER (ESR1) Hs-ESR1
PR (PGR) Hs-PGR
GATA3 Hs-GATA3
PD-L1 (CD274) Hs-CD274
GCDFP15 (PIP) Hs-PIP

Cervical Pathology

Marker Probe Name
HPV 16 HPV 16
HPV 18 HPV 18
HPV 16/18 HPV 16/18
HPV 6 HPV 6
HPV 11 HPV 11
HPV 6/11 HPV 6/11
HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82) HPV HR18
HPV High Risk 7 Pool (16, 18, 31, 33, 35, 52, & 58) HPV HR7
HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44) HPV LR6
P16 (CDKN2A) Hs-CDKN2A

Colorectal Pathology

Marker Probe Name
EGFR Hs-EGFR
MLH1 Hs-MLH1
MSH2 Hs-MSH2
MSH6 HS-MSH6
PMS2 Hs-PMS2-01
PD-L1 (CD274) Hs-CD274

Dermatopathology

Marker Probe Name
Merkel Cell Polyoma Virus V-MCPyV-LT-ST-Ag
PD-L1 (CD274) Hs-CD274
HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82) HPV HR18
HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44) HPV LR6

Gynecologic Pathology

Marker Probe Name
PAX8 Hs-PAX8
BRCA1 Hs-BRCA1
P53 Hs-TP53

Head and Neck Pathology

Marker Probe Name
HPV 16 HPV 16
HPV 18 HPV 18
HPV 45 HPV 45
HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82) HPV HR18
HPV High Risk 7 Pool (16, 18, 31, 33, 35, 52, & 58) HPV HR7
HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44) HPV LR6
P16 (CDKN2A) Hs-CDKN2A
PD-L1 (CD274) Hs-CD274

Hematopathology

Marker Probe Name
EBV EBV EBER-1
Kappa Hs-IGK
Lambda Hs-IGL
IGLL5 Hs-IGLL5
CXCL13 Hs-CXCL13
IRTA1 (FCRL4) Hs-FCRL4
PD-L2 (PDCD1LG2) Hs-PDCD1LG2-01
PD-L1 (CD274) Hs-CD274
Annexin A1 (ANXA1) Hs-ANXA1
Bartonella hensalae B-B.henselae-23SrRNA

Infectious Disease Pathology

Marker Probe Name
EBV EBV EBER-1
CMV CMV
HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82) HPV HR18
HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44) HPV LR6
BK Virus V-BKV
Merkel Cell Polyoma Virus V-MCPyV-LT-ST-Ag
Zika Virus V-ZIKA-pp
Bartonella hensalae B-B.henselae-23SrRNA
Mycobacteria tuberculosis (MTB) B-MTB
Non-tuberculous mycobacteria (NTM) B-NTM

Liver Pathology

Marker Probe Name
Albumin Albumin

Lung Pathology

Marker Probe Name
TTF-1 TTF-1
Napsin A Napsin A
ROS1 Translocation Hs-ROS1-E35-E43
ALK Translocation Hs-ALK-E19-E29
PD-L1 (CD274) Hs-CD274

Soft Tissue Pathology

Marker Probe Name
TLE1 Hs-TLE1-01
FGF23 Hs-FGF23

Thyroid & Endocrine Pathology

Marker Probe Name
TTF-1 TTF-1
PAX8 Hs-PAX8
Chromogranin A Hs-CHGA
Synaptophysin Hs-SYP
CD56 (NCAM1) Hs-NCAM1

Uropathology

Marker Probe Name
PAX8 Hs-PAX8
BK Virus V-BKV
GATA3 Hs-GATA3
PD-L1 (CD274) Hs-CD274
PTEN Hs-PTEN
AR (Androgen Receptor) Hs-AR
ERG Hs-ERG
ETV1 Hs-ETV1
ETV4 Hs-ETV4
ETV5 Hs-ETV5
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