Professional Assay Services (PAS) provides GCLP-compliant RNAscope, BaseScope™, miRNAscope™ in situ hybridization (ISH) assay services to support clinical and pre-clinical studies for our academic and biopharma partners. We provide end-to-end solutions from sample procurement to ISH staining to image analysis and reporting. Researchers who partner with Professional Assay Services will receive access to the most specialized and technically experienced RNAscope services of any CRO, provided by an expert multi-disciplinary team that includes PhD scientists and MDs, who serve our clients as technical experts, image analysis specialists and board-certified pathologists, spanning a broad array of scientific disciplines. With direct access to the developers of the technology, the PAS team provides unparalleled expertise in Bio-Techne's ISH platforms and delivers fast, high-quality data designed to meet your study objectives and timelines.
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Power Your Next Breakthrough from Target Validation to Clinical Development with RNAscope™ Professional Highlights Assay Services
Why Choose PAS as your ISH and Multiomic service provider?
- A decade of experience as a service provider, delivering 15,000+ stained slides per year
- An established history of servicing 28 of the 30 global pharmaceutical companies as well as dozens of cell and gene therapy biotech companies
- Ph.D. level scientists and MD pathologists who are specialized experts and provide scientific consultation for study design and data interpretation
What We Offer: Tissue-Based Expression Analysis
- Target validation. Screen and validate candidate targets by assessing target expression levels in drug-treated versus naïve samples or disease vs normal tissues
- Biomarker assay development. Evaluate candidate biomarker expression and establish assay performance and dynamic range using bioanalytical method validation guidelines
- AAV biodistribution. Profile the spatial distribution of AAV vector together with genetically modified transgenes to assess biodistribution and safety
- CAR/TCR biodistribution and function. Visualize the biodistribution of CAR T or TCR T cells within the tumor microenvironment and assess functionality with co-detection of immune cell markers and/or markers of activation
- Safety/toxicology tissue screening. Single-molecule detection for high sensitivity screening of normal tissues for pre-clinical ADME and safety assessment
- CDx assay development. Partner with ACD to support the assay prototype development, proof of concept and validation steps of your RNAscope CDx assay
We are supporting a broad range of pre-clinical and clinical applications in every therapeutic area including:
Resources
Publications
Berezhnoy A, Sumrow BJ, Stahl K, Shah K, Liu D, Li J, Hao SS, De Costa A, Kaul S, Bendell J, Cote GM, Luke JJ, Sanborn RE, Sharma MR, Chen F, Li H, Diedrich G, Bonvini E, Moore PA. Cell Rep Med. 2020 Dec 22
Yasuda M, Huston MW, Pagant S, Gan L, St Martin S, Sproul S, Richards D, Ballaron S, Hettini K, Ledeboer A, Falese L, Cao L, Lu Y, Holmes MC, Meyer K, Desnick RJ, Wechsler T. Mol Ther Methods Clin Dev. 2020 Jul 9
Ramachandran, I., Lowther, D. E., Dryer-Minnerly, R., Wang, R., Fayngerts, S., Nunez, D., Betts, G., Bath, N., Tipping, A. J., Melchiori, L., Navenot, J. M., Glod, J., Mackall, C. L., D'Angelo, S. P., Araujo, D. M., Chow, W. A., Demetri, G. D., Druta, M., Van Tine, B. A., Grupp, S. A., … Basu, S. J Immunother Cancer. 2019 Oct 24
Wang L, Lee G, Kuei C, Yao X, Harrington A, Bonaventure P, Lovenberg TW, Liu C. Front. Neurosci., 2019 March 26
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK, Foltz LA, Muppidi A, Alsina-Fernandez J, Barnard GC, Tang JX, Liu X, Mao X, Siegel R, Sloan JH, Mitchell PJ, Zhang BB, Gimeno RE, Shan B, Wu X. Nature Medicine . 2017 August 28
Eva Schrom, Maja Huber, Manish Aneja, Christian Dohmen, Daniela Emrich, Johannes Geiger, Günther Hasenpusch, Annika Herrmann-Janson, Verena Kretzschmann, Olga Mykhailyk, Tamara Pasewald, Prajakta Oak, Anne Hilgendorff, Dirk Wohlleber, Heinz-Gerd Hoymann, Dirk Schaudien, Christian Plank, Carsten Rudolph, Rebekka Kubisch-Dohmen. Mol Ther Nuc Acids. 2017 May 05
Qu, X., Sandmann, T., Frierson, H., Jr, Fu, L., Fuentes, E., Walter, K., Okrah, K., Rumpel, C., Moskaluk, C., Lu, S., Wang, Y., Bourgon, R., Penuel, E., Pirzkall, A., Amler, L., Lackner, M. R., Tabernero, J., Hampton, G. M., & Kabbarah, O. Oncogene, 2016 Dec 5
Functional annotation of the vlinc class of non-coding RNAs using systems biology approach.
St Laurent, G., Vyatkin, Y., Antonets, D., Ri, M., Qi, Y., Saik, O., Shtokalo, D., de Hoon, M. J., Kawaji, H., Itoh, M., Lassmann, T., Arner, E., Forrest, A. R., FANTOM consortium, Nicolas, E., McCaffrey, T. A., Carninci, P., Hayashizaki, Y., Wahlestedt, C., & Kapranov, P. Nucleic acids research. 2016 Apr 20
Overexpression of the Long Non-coding RNA SChLAP1 Independently Predicts Lethal Prostate Cancer
Mehra R, Udager AM, Ahearn TU, Cao X, Feng FY, Loda M, Petimar JS, Kantoff P, Mucci LA, Chinnaiyan AM. Eur Urol. 2016 Oct.
FGFR1 and FGFR2 in Fibrolamellar Carcinoma
Graham RP, Garcia JJ, Greipp PT, Barr Fritcher EG, Kipp BR, Torbenson MS. FGFR1 and FGFR2 in fibrolamellar carcinoma. Histopathology. 2016 Apr
Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung
Lafkas D, Shelton A, Chiu C, de Leon Boenig G, Chen Y, Stawicki SS, Siltanen C, Reichelt M, Zhou M, Wu X, Eastham-Anderson J, Moore H, Roose-Girma M, Chinn Y, Hang JQ, Warming S, Egen J, Lee WP, Austin C, Wu Y, Payandeh J, Lowe JB, Siebel CW. Nature. 2015 Dec 3;
DNAJB1-PRKACA is specific for fibrolamellar carcinoma.
Graham RP, Jin L, Knutson DL, Kloft-Nelson SM, Greipp PT, Waldburger N, Roessler S, Longerich T, Roberts LR, Oliveira AM, Halling KC, Schirmacher P, Torbenson MS. Mod Pathol. 2015 Jun
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.
Tap WD, Wainberg ZA, Anthony SP, Ibrahim PN, Zhang C, Healey JH, Chmielowski B, Staddon AP, Cohn AL, Shapiro GI, Keedy VL, Singh AS, Puzanov I, Kwak EL, Wagner AJ, Von Hoff DD, Weiss GJ, Ramanathan RK, Zhang J, Habets G, Zhang Y, Burton EA, Visor G, Sanftner L, Severson P, Nguyen H, Kim MJ, Marimuthu A, Tsang G, Shellooe R, Gee C, West BL, Hirth P, Nolop K, van de Rijn M, Hsu HH, Peterfy C, Lin PS, Tong-Starksen S, Bollag G. N Engl J Med. 2015 Jul 30;373(5):428-37
Ryner L, Guan Y, Firestein R, Xiao Y, Choi Y, Rabe C, Lu S, Fuentes E, Huw LY, Lackner MR, Fu L, Amler LC, Bais C, Wang Y. Clin Cancer Res. 2015 Jul 1
Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR. Stem Cell Reports. 2015 Jun 3
O'Shannessy DJ, Somers EB, Wang LC, Wang H, Hsu R. J Ovarian Res. 2015 May 14
