With our wide portfolio of ready-to-use probes, ACD provides a broad range of high-quality RNAscope probes for your RNA ISH needs in Anatomical Pathology. We have categorized the key RNAscope probes into thirteen Anatomical Pathology panels, based upon most common tumor, tissue and infectious disease types. Each panel includes RNAscope probes designed to enhance assessment and characterization of target markers in the organ-specific disease states. The Anatomical Pathology panels provide labs with the opportunity to add new markers to complement and add additional confirmation to their traditional IHC panels. 

Why choose RNAscope™ ISH for your panels?

• Unparalleled sensitivity and specificity - Detect any marker of interest to complement your IHC or DNA ISH, with consistently reliable results

• Surpass traditional IHC challenges - Easy validation, omit issues with high background, low signal or suboptimal antibodies

• Choose your platform - Optimize your workflow, RNAscope™ ISH probes are available and ready-to-use in both manual and automated formats. RNAscope probes have been developed for full automation on the Leica BOND and Ventana Discovery platforms

• Intuitive protocol, implemented seamlessly into your workflow - The RNAscope™ ISH protocol is easy to follow, similar in many steps to IHC and can be transferred to your established staining platform* with ease

*for Leica BOND and Ventana Discovery platforms

Ease of Data Analysis

RNAscope™ ISH is easy to interpret and quantify, with a single punctate dot representing 1 RNA molecule, unlike scoring with IHC. In this Non-Small Cell Lung Cancer (NSCLC) FFPE sample, each single dot represents a PDL1 RNA molecule. Tumor is highly heterogeneous, with low, medium and high regions of expression identified.