Target probe panels for anatomic pathology

With our wide portfolio of ready-to-use probes, ACD provides a broad range of high-quality RNAscope probes for your RNA ISH needs in Anatomical Pathology. We have categorized the key RNAscope probes into thirteen Anatomical Pathology panels, based upon most common tumor, tissue and infectious disease types. Each panel includes RNAscope probes designed to enhance assessment and characterization of target markers in the organ-specific disease states. The Anatomical Pathology panels provide labs with the opportunity to add new markers to complement and add additional confirmation to their traditional IHC panels. 

Why choose RNAscope® ISH for your panels?

  • Unparalleled sensitivity and specificity - Detect any marker of interest to complement your IHC or DNA ISH, with consistently reliable results

  • Surpass traditional IHC challenges - Easy validation, omit issues with high background, low signal or suboptimal antibodies

  • Choose your platform - Optimize your workflow, RNAscope® ISH probes are available and ready-to-use in both manual and automated formats. RNAscope probes have been developed for full automation on the Leica BOND and Ventana Discovery platforms

  • Intuitive protocol, implemented seamlessly into your workflow - The RNAscope® ISH protocol is easy to follow, similar in many steps to IHC and can be transferred to your established staining platform* with ease

*for Leica BOND and Ventana Discovery platforms

Ease of Data Analysis

RNAscope® ISH is easy to interpret and quantify, with a single punctate dot representing 1 RNA molecule, unlike scoring with IHC. In this Non-Small Cell Lung Cancer (NSCLC) FFPE sample, each single dot represents a PDL1 RNA molecule. Tumor is highly heterogeneous, with low, medium and high regions of expression identified.

List of Panel

Breast Pathology

MarkerProbe Name
HER2 (ERBB2)Hs-ERBB2
ER (ESR1)Hs-ESR1
PR (PGR)Hs-PGR
GATA3Hs-GATA3
PD-L1 (CD274)Hs-CD274
GCDFP15 (PIP)Hs-PIP

Cervical Pathology

MarkerProbe Name
HPV 16HPV 16
HPV 18HPV 18
HPV 16/18HPV 16/18
HPV 6HPV 6
HPV 11HPV 11
HPV 6/11HPV 6/11
HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82)HPV HR18
HPV High Risk 7 Pool (16, 18, 31, 33, 35, 52, & 58)HPV HR7
HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44)HPV LR6
P16 (CDKN2A)Hs-CDKN2A

Colorectal Pathology

MarkerProbe Name
EGFRHs-EGFR
MLH1Hs-MLH1
MSH2Hs-MSH2
MSH6HS-MSH6
PMS2Hs-PMS2-01
PD-L1 (CD274)Hs-CD274

Dermatopathology

MarkerProbe Name
Merkel Cell Polyoma VirusV-MCPyV-LT-ST-Ag
PD-L1 (CD274)Hs-CD274
HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82)HPV HR18
HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44)HPV LR6

Gynecologic Pathology

MarkerProbe Name
PAX8Hs-PAX8
BRCA1Hs-BRCA1
P53Hs-TP53

Head and Neck Pathology

MarkerProbe Name
HPV 16HPV 16
HPV 18HPV 18
HPV 45HPV 45
HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82)HPV HR18
HPV High Risk 7 Pool (16, 18, 31, 33, 35, 52, & 58)HPV HR7
HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44)HPV LR6
P16 (CDKN2A)Hs-CDKN2A
PD-L1 (CD274)Hs-CD274

Hematopathology

MarkerProbe Name
EBVEBV EBER-1
KappaHs-IGK
LambdaHs-IGL
IGLL5Hs-IGLL5
CXCL13Hs-CXCL13
IRTA1 (FCRL4)Hs-FCRL4
PD-L2 (PDCD1LG2)Hs-PDCD1LG2-01
PD-L1 (CD274)Hs-CD274
Annexin A1 (ANXA1)Hs-ANXA1
Bartonella hensalaeB-B.henselae-23SrRNA

Infectious Disease Pathology

MarkerProbe Name
EBVEBV EBER-1
CMVCMV
HPV High Risk 18 Pool (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, & 82)HPV HR18
HPV Low Risk 6 Pool (6, 11, 40, 42, 43, & 44)HPV LR6
BK VirusV-BKV
Merkel Cell Polyoma VirusV-MCPyV-LT-ST-Ag
Zika VirusV-ZIKA-pp
Bartonella hensalaeB-B.henselae-23SrRNA
Mycobacteria tuberculosis (MTB)B-MTB
Non-tuberculous mycobacteria (NTM)B-NTM

Liver Pathology

MarkerProbe Name
AlbuminAlbumin

Lung Pathology

MarkerProbe Name
TTF-1TTF-1
Napsin ANapsin A
ROS1 TranslocationHs-ROS1-E35-E43
ALK TranslocationHs-ALK-E19-E29
PD-L1 (CD274)Hs-CD274

Soft Tissue Pathology

MarkerProbe Name
TLE1Hs-TLE1-01
FGF23Hs-FGF23

Thyroid & Endocrine Pathology

MarkerProbe Name
TTF-1TTF-1
PAX8Hs-PAX8
Chromogranin AHs-CHGA
SynaptophysinHs-SYP
CD56 (NCAM1)Hs-NCAM1

Uropathology

MarkerProbe Name
PAX8Hs-PAX8
BK VirusV-BKV
GATA3Hs-GATA3
PD-L1 (CD274)Hs-CD274
PTENHs-PTEN
AR (Androgen Receptor)Hs-AR
ERGHs-ERG
ETV1Hs-ETV1
ETV4Hs-ETV4
ETV5Hs-ETV5
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