In Situ Hybridization, RNA-ISH

Search RNAscope^® Control and Target Probes

Available for >13,000 targets across >140 species including gene families and signaling pathways targets. Probes for new targets available in 2 weeks.

Search Catalog Control & Target Probes

Gene

Species

Biopharma Feature

Detect, localize and quantify vector and therapeutic transgenes

With RNAscope^® and BaseScope™ Assays

Learn More

Biopharma Feature

Visualize and quantify expression of multiple checkpoint and immune cell markers

With RNAscope^® and BaseScope™ Assays

Learn More

Biopharma Feature

Assess drug safety with unmatched sensitivity and specificity for any target in any tissue for any species

With RNAscope^® Assays

Learn More

Biopharma Feature

Species-specific gene expression profiling of patient-derived xenograft tumors

With RNAscope^® Assays

Learn More

Fig 12: Detection of G protein-coupled receptors (GPCRs) in normal mouse brain hippocampus using RNAscope<sup>®</sup>2.5 HD Duplex Chromogenic assay on FFPE tissue samples: Cnr1 (Red) and Drd1 (Green). Cells are counterstained with hematoxylin.

Fig 12: Detection of G protein-coupled receptors (GPCRs) in normal mouse brain hippocampus using RNAscope^®2.5 HD Duplex Chromogenic assay on FFPE tissue samples: Cnr1 (Red) and Drd1 (Green). Cells are counterstained with hematoxylin.

Fig 11: Detection of G protein-coupled receptors (GPCRs) in normal mouse brain hippocampus using RNAscope<sup>®</sup>2.5 HD Duplex Chromogenic assay on FFPE tissue samples: Cnr1 (Red) and Drd1 (Green). Cells are counterstained with hematoxylin.

Fig 11: Detection of G protein-coupled receptors (GPCRs) in normal mouse brain hippocampus using RNAscope^®2.5 HD Duplex Chromogenic assay on FFPE tissue samples: Cnr1 (Red) and Drd1 (Green). Cells are counterstained with hematoxylin.

Fig 10: Detection of the effector immediate early gene and plasticity marker Arc (Green) and GPCR Drd1 (Red) in mouse brain striatum using the RNAscope^® Multiplex Fluorescent assay on Fresh Frozen tissue samples.

Fig 9: Detection of transcription factor immediate early gene and activity marker Cfos (Green) and GPCR Chrm3 (Red) in mouse hippocampus using the RNAscope^® Multiplex Fluorescent assay on Fresh Frozen samples. Cells are counterstained with DAPI.

Fig 8: Fluorescent detection of ion channels. Detection of Asic1 (Green) and Kcnj3 (Red) in mouse brain hippocampus using the RNAscope<sup>®</sup> Multiplex Fluorescent assay on Fresh Frozen tissue samples.

Fig 8: Fluorescent detection of ion channels. Detection of Asic1 (Green) and Kcnj3 (Red) in mouse brain hippocampus using the RNAscope^® Multiplex Fluorescent assay on Fresh Frozen tissue samples.

Fig 7: Detection of G protein-coupled receptors (GPCRs) in mouse brain hippocampus using the RNAscope<sup>®</sup> Multiplex Fluorescent assay on Fresh Frozen tissue samples: Cnr1 (Green) and Drd1 (Red). Cells are counterstained with DAPI.

Fig 7: Detection of G protein-coupled receptors (GPCRs) in mouse brain hippocampus using the RNAscope^® Multiplex Fluorescent assay on Fresh Frozen tissue samples: Cnr1 (Green) and Drd1 (Red). Cells are counterstained with DAPI.

Today's Featured Data

Neuroscience Data Images

See application

Announcements

Literature

RNAscope^® Data Analysis Guide

Data analysis guidelines for several types of RNAscope^® staining results, including semi-quantitative and quantitative analysis methods.

Learn More

Promotion

Refer a Friend

Receive a discount of $/€ 500 off the next order, for both you and your colleagues, when entering our referral program.

Start Today

Featured

Overcome IHC Challenges with RNAscope^® Technology

Get outstanding sensitivity and detect biomarkers with ease.

Learn More

Webinar

CAR-T Cell Target Selection and Preclinical Safety Assessment with RNAscope^® ISH

Presented by James B. Rottman
Sr. Director, Translational Development, bluebird bio

Watch Now

Literature

RNAscope^® Reference Guide

Guidelines and protocols for obtaining optimal RNAscope^® in situ hybridization results with any tissue type from any species

Learn more

Upcoming Events

Webinar

19

July, 2018

Get More Data from Every Tissue Sample; Increasing Efficiency of Your ...

View details

Webinar

25

July, 2018

Single-Molecule RNA in situ Hybridization Assays for The Detection Of ...

View details

Webinar

31

July, 2018

RNAscope^® and BaseScope™ Assays are ideal tools to complement techn...

View details

Webinar

02

August, 2018

Harnessing in situ transcriptomics to reveal complex tissue architectu...

View details

View all

What to Buy

Step-by-step instructions to help you find the right products and accessories, learn best practices and get the best results from your assay.

Go to Buying Guide

Let us run your Biomarker assays

Get high quality gene expression data in just a few weeks.

Learn more

Work smarter - Not harder

Sigal et al. used 46 RNAscope^® probes to thoroughly characterize the gastric antral gland stem cell niche.

See publication

Mark the Pathway

Analyze all genes of a pathway with RNAscope^® ISH assays e.g. WNT/ β-catenin pathway | JAK/STAT signaling pathway | Akt Signaling Pathway.

Visualize all genes of a pathway

Validate your data

Use RNAscope^® ISH as a validation tool applied downstream of discoveries made with NGS, Microarrays, NanoString nCounter.

See publications

Visualize the invisible

Use RNAscope^® assays to detect & visualize long non-coding RNA.

Visualize targets like long non-coding RNAs

Stay curious for new discoveries

Use RNAscope^® assays to detect and characterize new markers and targets.

See publication on novel targets

Combine for Divine

Analyze RNA and protein simultaneously with ISH & IHC on the same tissue section.

Learn more on dual ISH/IHC

Get Advice from Experts

Watch webinars for tips & tricks or presentations from our customers.

Browse all webinars

Keep calm and read the famous manual

See all available manuals, check-lists and supporting literature.

Browse all manuals & documents

Take cellfies not selfies

View examples of RNA visualization with our RNAscope^® products.

See examples of gene expressions in different tissues

Reveal in true colors

Detect up to four targets - take advantage of the RNAscope^® multiplexing capability.

See all multiplexing publications

Search form

Detect, localize and quantify vector and therapeutic transgenes

Visualize and quantify expression of multiple checkpoint and immune cell markers

Assess drug safety with unmatched sensitivity and specificity for any target in any tissue for any species