In Situ Hybridization, RNA-ISH

Multi-omic profiling in situ
Introducing the New RNA-Protein Co-Detection Assays
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ASO, miRNA, and siRNA Detection with Spatial & Morphological Context
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RNAscope™
in situ hybridization probes for COVID-19 coronavirus are available
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RNA expression
like you've never
seen it before
Revolutionary RNAscope^® and BaseScope™ Assays
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area
Specific
Amplifies signal and simultaneously suppress noise
area
Sensitive
Detects single RNA molecules
area
Context
Detects RNA within conserved tissue or cell morphology
Expand your capabilities
with
The RNAscope^® HiPlex Assay
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Experience a new era of spatial genomics with the BaseScope™ Assay
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Enable your RNAscope & BaseScope projects with the award-winning Pharma Assay Services
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Biopharma Feature

Detect, localize and quantify vector and therapeutic transgenes

With RNAscope^® and BaseScope™ Assays

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Biopharma Feature

Visualize and quantify expression of multiple checkpoint and immune cell markers

With RNAscope^® and BaseScope™ Assays

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Biopharma Feature

Assess drug safety with unmatched sensitivity and specificity for any target in any tissue for any species

With RNAscope^® Assays

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Biopharma Feature

Species-specific gene expression profiling of patient-derived xenograft tumors

With RNAscope^® Assays

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Expression of IL6 RNA (red dots) in human colorectal cancer tissue, RNA in situ hybridization (ISH) using v

Lung cancer FFPE(RNA in situ hybridization ISH)

RNA expression of PTPRC (CD45) (green), IFNG (red) and of CD274 (PDL1) (white) in human lung cancer FFPE tissue using RNAscope LS Multiplex Fluorescent Assay

RNA expression of IFNG(red), CD274(green) gene in human lung cancer tissue using RNAscope<sup>®</sup> 2.5 HD Duplex Assay RNA in situ hybridization (ISH)

RNA expression of IFNG(red), CD274(green) gene in human lung cancer tissue using RNAscope^® 2.5 HD Duplex Assay

RNA expression of IDO1(green), IFNG(red) gene in human lung cancer tissue using RNAscope<sup>®</sup> 2.5 HD Duplex Assay RNA in situ hybridization (ISH)

RNA expression of IDO1(green), IFNG(red) gene in human lung cancer tissue using RNAscope^® 2.5 HD Duplex Assay

RNA expression of IL6 gene in Human Lymphoma tissue using RNAscope<sup>®</sup> 2.5 HD Assay Brown RNA in situ hybridization (ISH)

RNA expression of IL6 gene in Human Lymphoma tissue using RNAscope^® 2.5 HD Assay Brown

Expression of TNFA in Human Esophageal cancer tissue using RNAscope<sup>®</sup> 2.5 HD Assay Brown RNA in situ hybridization (ISH)

Expression of TNFA in Human Esophageal cancer tissue using RNAscope^® 2.5 HD Assay Brown

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September, 2020

2020 Sept 29: Introducing ACD's New RNA-Protein Co-Detection Assays...

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October, 2020

2020 Oct 6 - Longitudinal Immune Profiling Reveals Key Immune Signatur...

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October, 2020

CAP 2020 Virtual Conference...

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October, 2020

ASHG 2020 Virtual Conference...

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November, 2020

SITC 35th Anniversary 2020 - Virtual Conference...

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What to Buy

Step-by-step instructions to help you find the right products and accessories, learn best practices and get the best results from your assay.

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Let us run your Biomarker assays

Get high quality gene expression data in just a few weeks.

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Work smarter - Not harder

Sigal et al. used 46 RNAscope^® probes to thoroughly characterize the gastric antral gland stem cell niche.

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Mark the Pathway

Analyze all genes of a pathway with RNAscope^® ISH assays e.g. WNT/ β-catenin pathway | JAK/STAT signaling pathway | Akt Signaling Pathway.

Visualize all genes of a pathway

Validate your data

Use RNAscope^® ISH as a validation tool applied downstream of discoveries made with NGS, Microarrays, NanoString nCounter.

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Visualize the invisible

Use RNAscope^® assays to detect & visualize long non-coding RNA.

Visualize targets like long non-coding RNAs

Stay curious for new discoveries

Use RNAscope^® assays to detect and characterize new markers and targets.

See publication on novel targets

Combine for Divine

Analyze RNA and protein simultaneously with ISH & IHC on the same tissue section.

Learn more on dual ISH/IHC

Get Advice from Experts

Watch webinars for tips & tricks or presentations from our customers.

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Keep calm and read the famous manual

See all available manuals, check-lists and supporting literature.

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Take cellfies not selfies

View examples of RNA visualization with our RNAscope^® products.

See examples of gene expressions in different tissues

Reveal in true colors

Detect up to four targets - take advantage of the RNAscope^® multiplexing capability.

See all multiplexing publications

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Detect, localize and quantify vector and therapeutic transgenes

Visualize and quantify expression of multiple checkpoint and immune cell markers

Assess drug safety with unmatched sensitivity and specificity for any target in any tissue for any species

Species-specific gene expression profiling of patient-derived xenograft tumors

Inflammation Data Images

Upcoming Events

What to Buy

Let us run your Biomarker assays

Advanced Cell Diagnostics

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