RNAscope ISH for Companion Diagnostics (CDx)

There is an increasing need to stratify patients based on drug response, drug efficiency and risk of side effects. As a result, the need to develop RNA-based biomarkers and measure RNA expression has increased considerably. RNAscope™ ISH technology enables molecular detection in a morphological context; providing the cellular resolution required to evaluate tissue heterogeneity and to potentially better screen and select patients.

ACD’s Feasibility and Prototype Biomarker Assay Development Program

ACD’s Professional Assay Services offer a Feasibility and Prototype Biomarker Assay Development Program to assist laboratories in streamlining their assay development process; providing detailed optimized protocols and complete probe verification, reproducibility testing and data analysis as required, on a number of platforms, sample-types, study criteria, as required.

Learn more about our program.

Successful CDx Programs

Key Companion Diagnostic programs, recently reported via press release include:

Advanced Cell Diagnostics' RNAscope Technology Supports Biomarker-Selected Phase 2 Clinical Trial of Merrimack Pharmaceuticals' MM-121

HAYWARD, CALIFORNIA, March 9, 2015: Advanced Cell Diagnostics, Inc. announced that Merrimack Pharmaceuticals, Inc. is using ACD's RNAscope technology to select patients for its Phase 2 clinical trial of its product candidate MM-121. Merrimack will utilize RNAscope to identify patients with Heregulin positive, locally advanced or metastatic non-small cell lung cancer, making this Merrimack's first MM-121 trial to include only patients with a high Heregulin biomarker profile. The RNAscope-based companion diagnostic test under development for Merrimack's MM-121 detects mRNA of heregulin, a ligand for the drug target of MM-121, ERBB3.

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Bayer Develops Companion Diagnostic Test for Cancer Patients Together with Leica Biosystems

Leverkusen, December 21, 2016 – Bayer has entered into an agreement with Leica Biosystems to collaborate on the development of companion diagnostic tests based on tissue samples using RNAscope ® (a multiplex nucleic acid hybridization technology) and immunohistochemistry for cancer patients. Companion diagnostic tests aim to unlock molecular information from each patient to guide treatment decisions with targeted medications for cancer and other diseases.

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Partnership with Leica Biosystems

Take a look at our short video, describing our partnership and continued progress to advance clinical diagnostics via innovative technologies including RNA ISH.

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Advanced Cell Diagnostics

Our new headquarters office starting May 2016:

7707 Gateway Blvd.  
Newark, CA 94560
Toll Free: 1 (877) 576-3636
Phone: (510) 576-8800
Fax: (510) 576-8798



19 Barton Lane  
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OX14 3NB
United Kingdom
Phone 2: +44 1235 529449
Fax: +44 1235 533420


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20F, Tower 3,
Raffles City Changning Office,
1193 Changning Road, Shanghai 200051

Web: www.acdbio.com/cn

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