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DNAscope Duplex Assay

Sample 2 tumor appeared to be positive for ROS1 gene rearrangement indicated by break-apart event visualized as bright blue dots

Sample 2 tumor appeared to be positive for ROS1 gene rearrangement indicated by break-apart event visualized as bright blue dots

Sample 4 tumor appeared to be positive for ALK gene rearrangement indicated by break-apart event visualized as bright blue dots

Sample 4 tumor appeared to be positive for ALK gene rearrangement indicated by break-apart event visualized as bright blue dots

ERBB2-C1/CEP17q-C2

ERBB2-C1/CEP17q-C2

CDKN2A-C1/CEP9q-C2

CDKN2A-C1/CEP9q-C2

ALK WT BREAK-APART NEGATIVE CELL LINE

ALK WT BREAK-APART NEGATIVE CELL LINE

ALK BREAK-APART POSITIVE CELL LINE

ALK BREAK-APART POSITIVE CELL LINE

The DNAscope chromogenic duplex (red/blue) staining allows researchers to use a standard bright-field microscope to visualize and quantify gene copy number variations (amplifications/deletions) and gene rearrangements/fusions in tissues at  with spatial and morphological context at single cell resolution.

 

 

To get started with the DNAscope Duplex Assay you need:

DNAscope™ HD Duplex Reagent Kit - 324700

  • DNAscope™ HD Duplex Detection Reagents

  •  DNAscope Pretreatment Reagents Kit

  • 50x wash buffer

DNAscope Catalog Target Probes

Gene Name

Names

Catalog Number

ERBB2 (HER2)

DS-Hs-Her2-C1

1080031-C1

EGFR

DS-Hs-EGFR-C1

1080041-C1

MET

DS-Hs-MET-C1

1080051-C1

TP53

DS-Hs-TP53-C1

1080061-C1

CDKN2A

DS-Hs-CDKN2A-C1

1080071-C1

ALK

DS-Hs-ALK-BA5-C1

1080081-C1

ALK

DS-Hs-ALK-BA3-C2

1080091-C2

ROS1

DS-Hs-ROS1-BA5-C1

1080101-C1

ROS1

DS-Hs-ROS1-BA3-C2

1080111-C2

NTRK1

DS-Hs-NTRK1-BA5-C1

1080151-C1

NTRK1

DS-Hs-NTRK1-BA3-C2

1080161-C2

NTRK2DS-Hs-NTRK2-BA5-C11080171-C1
NTRK2DS-Hs-NTRK2-BA3-C21080181-C2
NTRK3DS-Hs-NTRK3-BA5-C11080191-C1
NTRK3DS-Hs-NTRK3-BA3-C21080201-C2

DNAscope Catalog Control Probes 

Gene Name

Names

Catalog Number

CEP3q

DS-Hs-CEP3q-C2

1080211-C2

CEP7q

DS-Hs-CEP7q-C2

1080221-C2

CEP9q

DS-Hs-CEP9p-C2

1080231-C2

CEP12p

DS-Hs-CEP12p-C2

1080241-C2

CEP17q

DS-Hs-CEP17q-C2

1080251-C2

 

 

 

 

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