Post-mortem Brain Tissue

Post-mortem Brain Tissue

Studies on the postmortem human brain have become a very important tool for understanding the neurobiology of neurodegenerative diseases or psychiatric disorders. Histology and immunohistochemistry are sometimes challenging due to technical limitations

mRNA in post mortem tissues is rapidly degraded after death and
formalin-based fixatives and embedding techniques can impair immunoreactivity. 

Therefore, some molecular markers, specifically expressed by a given neuronal population, cannot be assessed in human postmortem brain and novel techniques are needed to address this limitation.

RNAscope and BaseScope™ assays enable the investigation of postmortem human brain tissues by sensitive and specific mRNA detection. In a recent study, Bialas et al. detected human MX1 (403831), AIF1 (433121-C2) and ENO2 (421401) in human FFPE autopsy-derived brain tissue from the hippocampus using the RNAscope 2.5 HD Duplex Assay.

Data from our collaborator INSERM – University of Versailles-Saint-Quentin-en-Yvelines, U1179 'Neuromuscular Handicap', Montigny-le-Bretonneux (France) shows robust detection of mRNA in human postmortem tissue:

Application review

Learn more in our RNAscope Neuroscience Application Review - Cellular localization of RNA expression in central and peripheral nervous system using RNAscope Technology.

Cellular localization of RNA expression in central and peripheral nervous system using RNAscope Technology

Fill out the form below to download the application review:

Neuroscience Gene List

(click on gene name to access corresponding RNAscope probes)




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