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JAK/STAT Signaling Pathway

RNA expression of EGF gene (jak stat signaling pathway) in human breast cancer sample using RNAscope 2.0 HD Brown Assay and probe 605771 RNA in situ hybridization (ISH)

RNA expression of EGF gene in human breast cancer sample using RNAscope 2.0 HD Brown Assay and probe 605771

RNA expression of JAK2 gene (jak stat signaling pathway) in human colon cancer sample using RNAscope 2.0 HD Brown Assay and probe 403791 RNA in situ hybridization (ISH)

RNA expression of JAK2 gene in human colon cancer sample using RNAscope 2.0 HD Brown Assay and probe 403791

RNA expression of STAT1 gene (jak stat signaling pathway) in human esophageal cancer sample using RNAscope 2.5 HD Brown Assay and probe 469861 RNA in situ hybridization (ISH)

RNA expression of STAT1 gene in human esophageal cancer sample using RNAscope 2.5 HD Brown Assay and probe 469861

RNA expression of EGFR gene (jak stat signaling pathway) in human breast cancer sample using RNAscope 2.0 HD Brown Assay and probe 310061 RNA in situ hybridization (ISH)

RNA expression of EGFR gene in human breast cancer sample using RNAscope 2.0 HD Brown Assay and probe 310061

RNA expression of IFNB1 gene (jak stat signaling pathway) in human lymphoma sample using RNAscope 2.0 HD Brown Assay and probe 417071 RNA in situ hybridization (ISH)

RNA expression of IFNB1 gene in human lymphoma sample using RNAscope 2.0 HD Brown Assay and probe 417071

RNA expression of STAT1 gene (jak stat signaling pathway) in human glioma sample using RNAscope 2.5 HD Brown Assay and probe 469861 RNA in situ hybridization (ISH)

RNA expression of STAT1 gene in human glioma sample using RNAscope 2.5 HD Brown Assay and probe 469861

RNA expression of FGFR1 gene (jak stat signaling pathway) in human breast cancer sample using RNAscope 2.0 HD Brown Assay and probe 310071

RNA expression of FGFR1 gene in human breast cancer sample using RNAscope 2.0 HD Brown Assay and probe 310071

RNA expression of EGFR gene (jak stat signaling pathway) in human liver patient-derived xenograph (DPX) sample using RNAscope 2.5 HD Brown Assay and probe 418731 RNA in situ hybridization (ISH)

RNA expression of EGFR gene in human liver patient-derived xenograph (DPX) sample using RNAscope 2.5 HD Brown Assay and probe 418731

RNA expression of STAT1 gene (jak stat signaling pathway) in human lymphoma sample using RNAscope 2.5 HD Brown Assay and probe 469861 RNA in situ hybridization (ISH)

RNA expression of STAT1 gene in human lymphoma sample using RNAscope 2.5 HD Brown Assay and probe 469861

RNA expression of IL6 gene in Human Bladder cancer tissue using RNAscope<sup>®</sup> 2.5 HD Assay Brown RNA in situ hybridization (ISH)

RNA expression of IL6 gene in Human Bladder cancer tissue using RNAscope® 2.5 HD Assay Brown

RNA expression of HGF gene (jak stat signaling pathway) in liver patient-derived xenograph (DPX) sample using RNAscope 2.5 HD Brown Assay and probe 441421 RNA in situ hybridization (ISH)

RNA expression of HGF gene in liver patient-derived xenograph (DPX) sample using RNAscope 2.5 HD Brown Assay and probe 441421

RNA expression of JAK1 gene (jak stat signaling pathway) in human lymphoma sample using RNAscope 2.5 HD Brown Assay and probe 477581 RNA in situ hybridization (ISH)

RNA expression of JAK1 gene in human lymphoma sample using RNAscope 2.5 HD Brown Assay and probe 477581

RNA expression of IFNG gene (jak stat signaling pathway) in human vular cancer sample using RNAscope 2.5 HD Brown Assay and probe 310501 RNA in situ hybridization (ISH)

RNA expression of IFNG gene in human vular cancer sample using RNAscope 2.5 HD Brown Assay and probe 310501

RNA expression of STAT6 gene (jak stat signaling pathway) in human liver cancer sample using RNAscope 2.5 HD Brown Assay and probe 468591 RNA in situ hybridization (ISH)

RNA expression of STAT6 gene in human liver cancer sample using RNAscope 2.5 HD Brown Assay and probe 468591

RNA expression of EFNA4 gene (jak stat signaling pathway) in human breast cancer sample using RNAscope 2.0 HD Brown Assay and probe 557791 RNA in situ hybridization (ISH)

RNA expression of EFNA4 gene in human breast cancer sample using RNAscope 2.0 HD Brown Assay and probe 557791

RNA expression of JAK2 gene (jak stat signaling pathway) in human breast cancer sample using RNAscope 2.0 HD Brown Assay and probe 403791 RNA in situ hybridization (ISH)

RNA expression of JAK2 gene in human breast cancer sample using RNAscope 2.0 HD Brown Assay and probe 403791

RNA expression of STAT6 gene (jak stat signaling pathway) in human ovarian cancer sample using RNAscope 2.5 HD Brown Assay and probe 468591 RNA in situ hybridization (ISH)

RNA expression of STAT6 gene in human ovarian cancer sample using RNAscope 2.5 HD Brown Assay and probe 468591

RNA expression of ERBB2 gene in human breast cancer tissue using RNAscope<sup>®</sup> 2.5 HD Assay Brown RNA in situ hybridization (ISH)

RNA expression of ERBB2 gene in human breast cancer tissue using RNAscope® 2.5 HD Assay Brown

jak stat signaling pathway

 

Pathway information and image are provided courtesy of R&D Systems, a Bio-Techne Brand. To access the larger and interactive version of the pathway image visit their website.

 

The Janus family of tyrosine kinases (JAK) and the signal transducer and activator of transcription (STAT) family is a major signaling pathway involved in cellular metabolism. The JAK/STAT singnaling pathway is also involved in several cellular processes, such as proliferation, apoptosis, differentiation, and migration. Additionally, dysregulation of the JAK/STAT signaling pathway is linked with a wide range of leukemias, lymphomas, head & neck cancers, melanomas and breast cancers. STAT proteins are activated by cytokines and other receptor kinases, including EGFR, FGFR, CSF1R, PDGFR and other G-protein coupled receptors. Transcription factor and receptor are often expressed at very low levels and therefore development of highly sensitive antibody has been difficult.   The ultra-high sensitivity and specificity of the RNAscope® assay provides an alternative robust detection method of these hard to detect mRNA targets.

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