Publications

Synthetic receptor signalling has the potential to endow adoptively transferred T cells with new functions that overcome major barriers in the treatment of solid tumours, including the need for conditioning chemotherapy1,2. Here we designed chimeric receptors that have an orthogonal IL-2 receptor extracellular domain (ECD) fused with the intracellular domain (ICD) of receptors for common γ-chain (γc) cytokines IL-4, IL-7, IL-9 and IL-21 such that the orthogonal IL-2 cytokine elicits the corresponding γc cytokine signal.

Heart failure encompasses a heterogeneous set of clinical features that converge on impaired cardiac contractile function1,2 and presents a growing public health concern. Previous work has highlighted changes in both transcription and protein expression in failing hearts3,4, but may overlook molecular changes in less prevalent cell types.

Itch triggers scratching, a behavioural defence mechanism that aids in the removal of harmful irritants and parasites1. Chemical itch is triggered by many endogenous and exogenous cues, such as pro-inflammatory histamine, which is released during an allergic reaction1. Mechanical itch can be triggered by light sensations such as wool fibres or a crawling insect2. In contrast to chemical itch pathways, which have been extensively studied, the mechanisms that underlie the transduction of mechanical itch are largely unknown.

Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional organs. Here we show that conjugation of 2'-O-hexadecyl (C16) to siRNAs enables safe, potent and durable silencing in the central nervous system (CNS), eye and lung in rodents and non-human primates with broad cell type specificity. We show that intrathecally or intracerebroventricularly delivered C16-siRNAs were active across CNS regions and cell types, with sustained RNA interference (RNAi) activity for at least 3 months.

Predatory hunting is an innate appetite-driven and evolutionarily conserved behavior essential for animal survival, integrating sequential behaviors including searching, pursuit, attack, retrieval, and ultimately consumption. Nevertheless, neural circuits underlying hunting behavior with different features remain largely unexplored. Here, we deciphered a novel function of lateral hypothalamus (LH) Calcium/calmodulin-dependent protein kinase Ⅱ α (CaMKIIα+ ) neurons in hunting behavior and uncovered upstream/downstream circuit basis.

猪圆环病毒(Porcine Ci rcovirus,PCV)包括PCV1、PCV2和PCV3以及新鉴定的PCV4。其中PCV1无致病性,PCV2主要引起仔猪断奶后多系统衰竭综合征(PMWS)等猪圆环病毒相关疾病,PCV3多见于皮炎肾病综合征(PDNS)和繁殖障碍症状的猪群,PCV4首次鉴定于患有呼吸道症状、肠炎和PDNS的病猪。由于猪圆环病毒通常造成PMWS、PDNS以及PRDC等猪圆环病毒相关疾病,因此,了解这些疾病的临床特征是初步诊断PCV感染的基础。实验室检测方法常作为临床上确诊PCV感染或PCV与其他猪病原体鉴别诊断的有力工具,越来越多的检测方法对临床上检测PCV提供了更多的选择。因此,本文就猪圆环病毒实验室核酸检测方法进行汇总,以期对临床上选择合适的方法检测圆环病毒提供参考。

In the last decade, single cell RNAsequencing (scRNAseq) has made significant advances in obtaining quantitative geneexpression of individual cells and identifying previously uncharacterized cell types and functions. However, scRNAseq technologies have the intrinsic limitation of losing original positional information during tissue dissociation into single cells.

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Tumor growth depends on angiogenesis. The complex tissue environment surrounding tumor cells, which is composed of a variety of resident and infiltrating host cells, secreted factors and extracellular matrix proteins, influences tumor angiogenesis and progression. Moreover, the tumor microenvironment contributes to determining therapeutic responses and resistance to therapy. The ability to block tumor resistance is related to the understanding of the cellular and molecular pathways activated in the tumor microenvironment.

Bladder exstrophy, as part of the exstrophy-epispadias complex, is characterised by a pathologically open and protruding organ. Despite improvements in surgical repair, many patients continue to have poorly contractile, low-capacity bladders. These pathophysiological features are associated with significant fibrosis and greater biomechanical stiffness of the bladder wall (1). The current investigation was designed to yield insight into changes to Wnt-signalling pathways, important in organ and tissue development, but also in the regulation of connective tissue deposition (2).