Publications

Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. Of the approximate ten to twenty million people currently infected worldwide, 4-9% of infected individuals develop adult T-cell leukemia/lymphoma (ATLL) or HTLV-associated myelopathy/tropical spastic paresis (HAM/TSP) in their lifetime. The current report is based on a patient who presented concurrently with CD30+ lymphoma subtype ATLL and HAM/TSP. The patient’s ATLL responded to brentuximab-vedotin-based chemotherapy; however, HAM/TSP did not improve.

Menopause is associated with the loss of LH ovulatory surges and enhanced visceral adiposity. Visceral fat depots increase from 5-8% at premenopause to 15-20% of total body fat at postmenopause. Here, we report that high-dose LH, hCG, or small molecule LH/CGR agonist ORG43553 injected twice-a-week into 14-weeks-old C57BL/6 male mice protects them from diet-induced obesity. Testosterone levels were elevated in mice treated with LH or hCG, but not with ORG43553.

Background: The identification of differentially expressed genes and their associated biological processes, molecular function, and cellular components are important for genetic diseases studies because they present potential biomarkers and therapeutic targets. Methods: In this study, we developed an o²S²PARC template representing an interactive pipeline for the gene expression data visualization and ontologies data analysis and visualization.  To demonstrate the usefulness of the tool, we performed a case study on a publicly available dataset.

目的 通过表达谱芯片筛选卵巢癌(OC)有价值的核心长链非编码RNAs(lncRNAs)分子,并进行表达验证和分析。方法 收集宁夏医科大学总医院2018年1月至2019年6月OC组织36份,正常卵巢组织22份,以表达谱芯片检测差异表达lncRNAs和mRNAs分子,以real-time PCR验证lncRNAs表达,原位杂交验证关键核心lncRNA的表达,生物信息学分析lncRNA可能的功能。结果 相比于正常组织,癌组织中共有4 982个差异表达的lncRNA,以锌指E盒结合同源盒蛋白2-AS1(ZEB2-AS1)的高表达最为显著(P＜0.05);ZEB2-AS1在肝癌、结肠癌和肾癌等多个癌组织中过表达;表达水平与肿瘤大小、病理分级、病理分型及临床分期均有相关性(P＜0.05),且高表达导致总生存期和无病生存期降低(P＜0.05)。ZEB2-AS1具有多个microRNA结合位点,与相应邻近基因ZEB2的表达情况一致。结论 ZEB2-AS1在卵巢癌中异常表达,提示ZEB2-AS1具有重要的研究价值。

Nutrient starvation drives yeast meiosis by inactivating mTORC1 and protein kinase A (PKA), while retinoic acid (RA) is required for mammalian meiosis through the activation of its germline target, _stimulated by retinoic acid gene 8 (Stra8)_.

Fibroblast growth factor (FGF) signaling plays several important roles in the development of the central nervous system. During the mid-gestation stage, FGF receptors (FGFRs) are expressed in the ventricular zone of the telencephalon and regulate the proliferation and neuronal differentiation of radial glial cells (RGCs). Inhibition of FGFR signaling at this stage results in abnormal brain formation, particularly loss of FGFR1 signaling causes hypoplasia of the olfactory bulb (OB). However, how FGFR1 signaling regulates OB formation is not fully understood.

There are few prostate cancer prognostic biomarkers. However, clinical difficulties in distinguishing between aggressive and non-aggressive tumors have been observed. CD73 is a 70-kDa glycosylphosphatidylinositol (GPI)-linked ecto-enzyme that reduces antitumor immunity in mouse models of tumor, particularly prostate cancer. It's believed to be a promising biomarker for predicting the clinical development and prognosis of certain tumor types. Its function in prostate cancer, however, is unknown.

Acid-sensing ion channels (ASICs) play a critical role in nociception in human sensory neurons. Four genes (ASIC1, ASIC2, ASIC3, and ASIC4) encoding multiple subunits through alternative splicing have been identified in humans. Real time-PCR experiments showed strong expression of three subunits ASIC1, ASIC2, and ASIC3 in human dorsal root ganglia; however, their detailed expression pattern in different neuronal populations has not been investigated yet.

We present a comprehensive analysis of SARS-CoV-2 infection and recovery in wild type C57BL/6 mice, demonstrating that this is an ideal model of infection and recovery that accurately phenocopies acute human disease arising from the ancestral SARS-CoV-2. Disease severity and infection kinetics are age- and sex-dependent, as has been reported for humans, with older mice and males in particular exhibiting decreased viral clearance and increased mortality.

PlexinA1 (PlxnA1) is a transmembrane receptor for semaphorins (Semas), a large family of axonal guidance cues vital during neural development. PlxnA1 is expressed in embryonic interneurons, and PlxnA1 deletion in mice leads to less interneurons in the developing cortex. In addition, PlxnA1 has been identified as a schizophrenia susceptibility gene. In our previous study, PlxnA1 knockout (KO) mice under a BALB/cAJ genetic background exhibited significantly increased self-grooming and reduced prepulse inhibition, a reliable phenotype for investigating the neurobiology of schizophrenia.