Comprehensive evaluation of the tumor microenvironment by RNAscope™ and BaseScope™, two highly specific and sensitive in situ hybridization methods.
Single molecule detection of specific transcripts in FFPE Tissue - a new standard for in situ Molecular Pathology
RNAscope™ is a proprietary RNA in situ hybridization (ISH) assay based on ACD patented signal amplification and background suppression technology which advances RNA biomarker analysis in tissues and cells. Unique to this technology, RNAscope™ delivers quantitative, sensitive and specific molecular detection of RNA species on a cell-by-cell basis with morphological context in a single assay. This enables researchers to visualize which genes are expressed, localize where they are expressed, and quantify the level of expression.
Key features
- Detection of a single RNA molecules. The RNAscope™ probe design provides robustness against partial target RNA accessibility or degradation.
- Signal amplification coupled with simultaneous background suppression strategy results in single-RNA-molecule detection even in partially degraded samples.
- Provides cell-specific expression information in intact tissue architecture.
- Works for virtually ANY gene from ANY species in ANY tissue.
