Push Boundaries with The New Breakthrough Technology for ASO, miRNA, and siRNA Detection
Detections of small non-coding RNAs such as microRNAs and short oligonucleotide therapeutics such as ASO and siRNA require a robust, highly specific and sensitive assay with minimal time and effort, , delivering data for easy interpretation. While microarrays and PCR both provide useful molecular profiles of diseases, important clinically relevant cell and tissue context information is lost along with the spatial variation of gene expression patterns. The miRNAscope™ Assay is a highly sensitive and specific in situ hybridization assay that allows for the visualization of ASO, miRNA, siRNA and other nucleic acid targets between 17-50 nucleotides expression in intact tissues or cultured cells with single-cell resolution, preserving spatial and morphological context.
The miRNAscope™ Assay is available for both the manual and automated (Leica Systems, LS) platforms.
The miRNAscope™ HD Manual AssayThe miRNAscope™ LS Assay
“Our experience working with ACD Bio has been all-around excellent. With their expertise and through clear communication, we developed several assays to detect both RNA and short oligonucleotides in tissue. Compared to standard complementary probes, the signal we obtained using ACD Bio was evident and specific. After seeing the first images, we immediately knew we wanted to use these techniques more frequently."
--Exicure, R&D Team
“We had a great experience using miRNAscope™ in our compound screening efforts. The technique is incredibly specific and the results are very easy to understand. Also, working with ACD’s team has been extremely beneficial. They communicated with us during the process to ensure we can get the answers to our questions. They generated impeccable tissue stainings!”
--A leading BioPharma company in NY, USA
App Note
Introducing the novel miRNAscope™ in situ hybridization assay for the robust detection of microRNAs and other small RNA targets with spatial resolution
EXPRESSION OF MATURE microRNAS,miR-1287-5p AND miR-658 IS UPREGULATED IN DIABETIC KIDNEY DISEASE (DKD) TISSUES
Poster
miRNAscope™ : a novel in situ hybridization technology for the detection of small regulatory RNAs with spatial and morphological context
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