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Search

Probes for INSULIN

ACD can configure probes for the various manual and automated assays for INSULIN for RNAscope Assay, or for Basescope Assay compatible for your species of interest.

Your search for "insulin" returned results. Search for our Top genes LGR5, vglut2, gad67, brca1

    Refine Probe List

    Content for comparison

    Gene

    • GCG (2) Apply GCG filter
    • CHRM3 (2) Apply CHRM3 filter
    • Ins2 (2) Apply Ins2 filter
    • Insr (1) Apply Insr filter
    • SLC30A8 (1) Apply SLC30A8 filter
    • CHGA (1) Apply CHGA filter
    • GLP1R (1) Apply GLP1R filter
    • GUCA2A (1) Apply GUCA2A filter
    • GUCA2B (1) Apply GUCA2B filter
    • LEPR (1) Apply LEPR filter
    • Fpr1 (1) Apply Fpr1 filter
    • Gpr81 (1) Apply Gpr81 filter
    • (-) Remove col10a1 filter col10a1 (1)
    • C3 (1) Apply C3 filter
    • DISC1 (1) Apply DISC1 filter
    • NCAM1 (1) Apply NCAM1 filter
    • Igfbp6 (1) Apply Igfbp6 filter
    • Adipoq (1) Apply Adipoq filter
    • IL25 (1) Apply IL25 filter
    • Gnb5 (1) Apply Gnb5 filter
    • Plcb2 (1) Apply Plcb2 filter
    • HEL (1) Apply HEL filter
    • IGF-1 (1) Apply IGF-1 filter
    • IGF-2 (1) Apply IGF-2 filter
    • insulin (1) Apply insulin filter
    • Tas2r108 (1) Apply Tas2r108 filter
    • (-) Remove IGFBP-2 filter IGFBP-2 (1)
    • IGFBP-3 (1) Apply IGFBP-3 filter
    • IGFBP-7 (1) Apply IGFBP-7 filter

    Product

    • RNAscope 2.5 HD Red assay (2) Apply RNAscope 2.5 HD Red assay filter

    Research area

    • (-) Remove Other filter Other (2)

    Category

    • Publications (2) Apply Publications filter
    Proteomic Analysis of Charcoal-Stripped Fetal Bovine Serum Reveals Changes in the Insulin-Like Growth Factor Signaling Pathway.

    J Proteome Res.

    2018 Jul 17

    Tu C, Fiandalo MV, Pop E, Stocking JJ, Azabdaftari G, Li J, Wei H, Ma D, Qu J, Mohler JL, Tang L, Wu Y.
    PMID: 30014700 | DOI: 10.1021/acs.jproteome.8b00135

    Fetal bovine serum (FBS) is used commonly in cell culture. Charcoal-stripped FBS (CS-FBS) is used to study androgen responsiveness and androgen metabolism in cultured CaP cells. Switching CaP cells from FBS to CS-FBS may reduce activity of androgen receptor (AR), inhibit cell proliferation, or modulate intracellular androgen metabolism. Removal of proteins by charcoal stripping may cause changes in biological functions. Proteins in FBS and CS-FBS were profiled using an ion current-based quantitative platform consisting of reproducible surfactant-aided precipitation/on-pellet digestion, long-column nano-liquid chromatography (LC) separation, and ion current-based analysis (ICan). A total of 143 proteins were identified in FBS, among which 14 proteins including insulin-like growth factor 2 (IGF-2) and IGF binding protein (IGFBP)-2 and -6 were reduced in CS-FBS. IGF1 receptor (IGF1R) and insulin receptor (IR) were sensitized to IGFs in CS-FBS. IGF1 and IGF2 stimulation fully compensated for the loss of AR activity to maintain cell growth in CS-FBS. Endogenous production of IGF and IGFBPs was verified in CaP cells and clinical CaP specimens. This study provided the most comprehensive protein profiles of FBS and CS-FBS, and offered an opportunity to identify new protein regulators and signaling pathways that regulate AR activity, androgen metabolism and proliferation of CaP cells.

    FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice.

    Endocrinology.

    2016 Oct 12

    Burt PM, Xiao L, Dealy C, Fisher MC, Hurley MM.
    PMID: 27732085 | DOI: 10.1210/en.2016-1548

    Humans with X-linked hypophosphatemia (XLH) and Hyp mice, the murine homologue of the disease, develop severe osteoarthropathy and the precise factors that contribute to this joint degeneration remain largely unknown. Fibroblast growth factor 2 (FGF2) is a key regulatory growth factor in osteoarthritis. Although there are multiple FGF2 isoforms the potential involvement of specific FGF2 isoforms in joint degradation has not been investigated. Mice that overexpress the high molecular weight FGF2 isoforms in bone (HMWTg mice) phenocopy Hyp mice and XLH subjects and Hyp mice overexpress the HMWFGF2 isoforms in osteoblasts and osteocytes. Since Hyp mice and XLH subjects develop osteoarthropathies we examined whether HMWTg mice also develop knee joint degeneration at 2, 8, and 18-month-old compared with VectorTg (control) mice. HMWTg mice developed spontaneous osteoarthropathy as early as 2 months of age with thinning of subchondral bone, osteophyte formation, decreased articular cartilage thickness, abnormal mineralization within the joint, increased cartilage degradative enzymes, hypertrophic markers, and angiogenesis. FGF receptors 1 and 3 and fibroblast growth factor 23 were significantly altered compared to VectorTg mice. In addition, gene expression of growth factors and cytokines including bone morphogenetic proteins, Insulin like growth factor 1, Interleukin 1 beta, as well transcription factors Sex determining region Y box 9, hypoxia inducible factor 1 and nuclear factor kappa B subunit 1 were differentially modulated in HMWTg compared with VectorTg. This study demonstrates that overexpression of the HMW isoforms of FGF2 in bone results in catabolic activity in joint cartilage and bone that leads to osteoarthropathy.

    X
    Description
    sense
    Example: Hs-LAG3-sense
    Standard probes for RNA detection are in antisense. Sense probe is reverse complent to the corresponding antisense probe.
    Intron#
    Example: Mm-Htt-intron2
    Probe targets the indicated intron in the target gene, commonly used for pre-mRNA detection
    Pool/Pan
    Example: Hs-CD3-pool (Hs-CD3D, Hs-CD3E, Hs-CD3G)
    A mixture of multiple probe sets targeting multiple genes or transcripts
    No-XSp
    Example: Hs-PDGFB-No-XMm
    Does not cross detect with the species (Sp)
    XSp
    Example: Rn-Pde9a-XMm
    designed to cross detect with the species (Sp)
    O#
    Example: Mm-Islr-O1
    Alternative design targeting different regions of the same transcript or isoforms
    CDS
    Example: Hs-SLC31A-CDS
    Probe targets the protein-coding sequence only
    EnEmProbe targets exons n and m
    En-EmProbe targets region from exon n to exon m
    Retired Nomenclature
    tvn
    Example: Hs-LEPR-tv1
    Designed to target transcript variant n
    ORF
    Example: Hs-ACVRL1-ORF
    Probe targets open reading frame
    UTR
    Example: Hs-HTT-UTR-C3
    Probe targets the untranslated region (non-protein-coding region) only
    5UTR
    Example: Hs-GNRHR-5UTR
    Probe targets the 5' untranslated region only
    3UTR
    Example: Rn-Npy1r-3UTR
    Probe targets the 3' untranslated region only
    Pan
    Example: Pool
    A mixture of multiple probe sets targeting multiple genes or transcripts

    Enabling research, drug development (CDx) and diagnostics

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