During this seminar, we will explore the role of RNAscope™ spatial profiling in mapping diverse RNA markers implicated in body weight regulation and their impact in obesity research. RNAscope in situ hybridization (ISH) spatial technology provides a powerful method to detect gene expression within the morphological tissue context. The proprietary “double Z” probe design in combination with the advanced signal amplification enables highly specific and sensitive detection of the target RNA with each dot visualizing a single RNA transcript. This robust signal-to-noise technology allows for the detection of gene transcripts at the single molecule level providing clear answers while seamlessly fitting into existing anatomic pathology workflows.