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2021 Mar 17 - Oncofetal ecosystem: space, time and memory
Ankur Sharma, Ph.D.,
Laboratory Head at Harry Perkins Institute of Medical Research and women’s cancer senior fellow/Senior lecturer at Curtin Health Innovation Research Institute (CHIRI), Curtin University, Perth, Australia.
Watch Video:
Anushka Dikshit, Ph.D.
Applications Scientist, Advanced Cell Diagnostics
Outline:

This webcast will describe employing single cell genomics and spatial transcriptomics to discover a previously unexplored oncofetal reprogramming of the tumor ecosystem. Analysis of ~212,000 cells representing human fetal, hepatocellular carcinoma (HCC), and mouse liver revealed remarkable fetal-like reprogramming of the tumor microenvironment. Specifically, the HCC ecosystem displayed features reminiscent of fetal development, including re-emergence of fetal-associated endothelial cells and fetal-like tumor-associated macrophages. The speaker will describe a shared immunosuppressive oncofetal ecosystem in fetal liver and HCC and its potential implications for targeting therapeutic interventions in HCC and identifying similar paradigms in other cancers and diseases.

Learning Objectives:
  • Identification of fetal-associated endothelial cells and macrophages in HCC
  • Shared oncofetal ecosystem between human fetal liver and HCC
  • The phenomenon of oncofetal reprogramming in the tumor ecosystem
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