2021 Dec 7 - An overview of a novel RNAscope™ in situ hybridization technology, and applications in pathology of animal models
Anushka Dikshit, Ph.D.
Applications Scientist, Genomics, Advanced Cell Diagnostics
Watch Video:
Sebastien Monette, DVM, MPVM, MSc, PhD
Veterinary pathologist and the Head of Anatomic Pathology at the Laboratory of Comparative Pathology
Outline:
The RNAscope technology allows high sensitivity and spatial resolution providing pivotal single-cell information to gain better insights into tumor immunology, the complex and heterogeneous tumor microenvironment and its dynamics in cancer initiation, progression, and metastasis. Using the different assays under the RNAscope technology umbrella, it is possible to simultaneously visualize and assess the gene expression of cytokines, chemokines, immune cell markers, tumor cell markers and checkpoint markers within the tumor microenvironment (TME). In this webinar you will learn about using the RNAscope technology to-
Learning Objectives:
- Understand complex spatial relationship among different cell types within the TME
- Profile immune checkpoint markers and other therapeutic targets
- Characterize immune cell types and activation states
- Detect splice variants and point mutations implicated in cancer
- Support development of effective cell therapies by visualizing engineered cells in pre- clinical models
