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2021 April 27: Introducing Novel Chromogenic ISH Assay for High-Resolution Detection of DNA Copy Number and Structural Variants
Madhura Nayak
Product Manager, Advanced Cell Diagnostics, a Bio-Techne Brand
Watch Video:
Vasudha Murlidhar, Ph.D.
Scientist, Advanced Cell Diagnostics, a Bio-Techne Brand
Outline:

Introducing ACD's new/ novel chromogenic in situ hybridization assay for high-resolution detection of DNA copy number and structural variations- DNAscope Assays. DNA ISH is a spatial profiling tool based on hybridizing labelled complementary probes to the target DNA inside the cell nucleus to visualize any genetic alterations in tissues. Learn how current limitations of the DNA ISH assay such as limited morphological detail, difficult interpretation and low resolution detection due to larger probe sizes are addressed by the new assay. The DNAscope chromogenic duplex (red/blue) staining allows researchers to use a standard bright-field microscope to visualize and quantify gene copy number variations (amplifications/deletions) and gene rearrangements/fusions in tissues with spatial and morphological context at single cell resolution.

Learning Objectives:
  • Spatial Visualization of any DNA target: Proven “double-Z” probe design and signal amplification system of RNAscope, enabling rapid and flexible probe development
  • ​Unparalleled performance in detecting small genomic regions/single gene locus ​- Amplify target-specific signals but not background noise from non-specific hybridization
  • Easy Interpretation and high throughput data analysis - Permanent chromogenic signal and superior morphological context
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