2020 Feb 18 - Genome-wide Study Reveals a Pseudogene-Associated Recurrent Gene Fusion in Prostate Cancer
Nallasivam Palanisamy, PhD
Associate Scientist & Professor, Vattikuti Urology Institute, Henry Ford Health System
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Anushka Dikshit, Ph.D.
Applications Scientist, Advanced Cell Diagnostics
Outline:
Pseudogenes are a class of non-coding RNA with unknown functions. While there have been anecdotal observations pseudogene candidates with distinct functional roles, the overall genome-wide expression of pseudogenes in cancer has not reported until recently, with the help of next-generation sequencing technology.
In this webinar, Nallasivam Palanisamy of the Henry Ford Health System will discuss an effort to understand the genome-wide expression of pseudogenes across several solid cancers, which revealed a novel gene fusion involving a pseudogene in prostate cancer.
Learning Objectives:
The objectives of this seminar are:
- To present an overview of pseudogene expression in cancer
- To discuss a method for the analysis and discovery of cancer-specific pseudogenes
- To outline the application of RNA in situ hybridization for the analysis of pseudogenes
