2018 Aug 2 - Harnessing in situ transcriptomics to reveal complex tissue architecture at single-cell resolution
Omer Bayraktar, Ph.D.
Wellcome Sanger Institute
Watch Video:
Xiao-Jun Ma, Ph.D.
Chief Scientific Officer, Advanced Cell Diagnostics

Sequencing of RNA (RNASeq) can provide a trove of useful information for quantification and characterization of the transcriptome. During bulk sequencing, however, spatial and cellular heterogeneity information is lost. Enter single-cell–level analysis, which can provide unprecedented detail on cellular diversity in development, health, and disease. This emerging area of spatial transcriptomics aims to map a single-cell–level molecular atlas of human tissues in situ. However, mapping entire tissue areas at single-cell quantitative resolution presents significant challenges for imaging and data analysis. In this webinar, efforts to develop large-scale in situ transcriptomics will be described, using the mouse brain as a model system for mapping the molecular diversity of neuronal and glial cell types. The experimental workflow includes automated tissue processing, imaging and analysis for large-scale multiplex mapping, and quantification of gene expression across brain regions in situ at single-cell resolution. The technology that makes this high-resolution mapping possible will be described and compared with other current methods.


Watch the on-demand recording of this webinar here

Learning Objectives:

During the webinar, the speakers will:

  • Describe the power and usefulness of in situ transcriptomics
  • Discuss the application of this technology to large-scale tissue mapping in the mouse brain
  • Explain how in situ transcriptomics (using RNAScope technology) can complement RNASeq and single-cell RNASeq
  • Answer audience questions during the live broadcast!

To learn more about products or technologies related to this webinar, go to http://rna.acdbio.com/transcriptomics.

This webinar will last for approximately 60 minutes.

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