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2020 May 21 - Tissue-based expression analysis by ACD’s in situ hybridization assay services — Simultaneous ISH/IHC Co-Detection of RNA and Protein Targets
Joe Chellow
Sr. Research Associate, Advanced Cell Diagnostics
Watch Video:
Xiomara Perez, Ph.D.
Scientist, Advanced Cell Diagnostics
Outline:

The RNAscope™ technology enables fast and rigorous target and biomarker development: it is a robust and ultra-sensitive RNA in situ hybridization (RNA ISH) method providing single-cell and single-molecule RNA detection in the context of complex tissue microenvironments. Advanced Cell Diagnostics’ Pharma Assay Services is the only CRO specialized in providing RNAscope and BaseScope ISH. In this webinar we will introduce assay service offerings that combine analysis of any target by RNAscope in situ hybridization (ISH) with immune cell and checkpoint marker immunohistochemistry (IHC) and immunofluorescence (IF) assays. Our services provide spatial analysis of target antigens, biomarkers, cytokines, or CAR-T cells together with immune cell distribution within the tumor microenvironment (TME). All RNAscope probes can be multiplexed together with our validated IHC and IF assays. We also provide quantitative image analysis of target expression within labeled cell populations using HALO™ software from Indica Labs. Please join us to hear how our services are contributing to and advancing the therapeutic development programs of hundreds of pharma and biotech companies worldwide.

Learning Objectives:
  • Use of ISH-IHC/IF assays to support preclinical immuno-oncol­ogy research and biomarker validation
  • Surveillance of immune cell and check-point markers in the TME

 

  • CAR-T and TCR T-cell tumor infiltration and activation in pre- vs post-treatment clinical biopsies
  • Validated ISH/IHC protocols for co-detection of biomarkers and immune cell markers
  • Quality-controlled tissue bank that includes solid tumors, normal human tissues, and TMAs available for target safety/ADME assessment or any other research needs

 

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