2020 Mar 24 - Tissue-based expression analysis by ACD’s in situ hybridization assay service — high resolution image data in as little as 4 weeks
Mansi Garg
Sr. Manager, Project Operations, Advanced Cell Diagnostics
Watch Video:
Outline:
Advanced Cell Diagnostics’ Professional Assay Services (PAS) is the only CRO specialized in visualizing and quantifying AAV and lentiviral-based gene and cell therapies in the tissue microenvironment. This webinar will introduce our RNAscope™ and BaseScope™ in situ hybridization (ISH) services, as well as our quantitative image analysis capabilities and quality-controlled tissue bank for target validation. Please join us to hear how our services are contributing to and advancing therapeutic programs of hundreds of pharma and biotech companies worldwide.
Learning Objectives:
- Biomarker validation to accelerate translation of assays into clinical development
- Gene therapy applications - morphology-based biodistribution analysis of AAV vector and transgene expression
- CAR-T and TCR-T cell tumor infiltration and activity assays
- Detection of splice variants, point mutations and short target sequences with BaseScope ISH assays
- Validated ISH/IHC protocols for co-detection of biomarkers and immune cell markers
- PAS’s quality-controlled tissue bank including solid tumors, normal human tissues, and TMAs
- Tissue sourcing and QC services for delivery of tissues with verified RNA quality for use in-house by our customers.
- Best practices for RNAscope image analysis with review of available methods for data interpretation and scoring
