Sensory Experience Shapes a Growing Brain: Regulation of Sensory-Dependent Circuit Refinement by TWEAK/Fn14 Cytokine Signaling
Lucas M. Cheadle, Ph.D.
Postdoctoral Fellow (Greenberg Lab), Dept of Neurobiology, Harvard Medical School
Watch Video:
Courtney Anderson, Ph.D.
Research Manager, Applications, Advanced Cell Diagnostics
Outline:

Sensory experience sculpts neural connectivity via cellular and molecular mechanisms that are still largely unknown. Through a combination of single-cell transcriptomics, structural analysis, and electrophysiology, Dr. Lucas Cheadle and colleagues identified the secreted cytokine TWEAK and its receptor Fn14 as important regulators of sensory-dependent synaptic remodeling. Hear from Cheadle about his use of multiplexed mRNA detection in situ with spatial resolution to reveal temporally coordinated, experience-dependent expression of TWEAK in microglia and Fn14 in excitatory neurons, suggesting that experience regulates circuit development by initiating complementary transcriptional programs in neuronal and non-neuronal cells. This webinar is sponsored by Advanced Cell Diagnostics.

Learning Objectives:

Topics to be covered:

  • Single-cell transcriptomics and in situ validation of sensory-driven gene expression
  • Sensory experience-dependent refinement of neural circuits by transcriptional control in activated neurons
  • Induction of TWEAK expression in microglia by sensory stimulation
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