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Sensory Experience Shapes a Growing Brain: Regulation of Sensory-Dependent Circuit Refinement by TWEAK/Fn14 Cytokine Signaling
Lucas M. Cheadle, Ph.D.
Postdoctoral Fellow (Greenberg Lab), Dept of Neurobiology, Harvard Medical School
Courtney Anderson, Ph.D.
Research Manager, Applications, Advanced Cell Diagnostics

Sensory experience sculpts neural connectivity via cellular and molecular mechanisms that are still largely unknown. Through a combination of single-cell transcriptomics, structural analysis, and electrophysiology, Dr. Lucas Cheadle and colleagues identified the secreted cytokine TWEAK and its receptor Fn14 as important regulators of sensory-dependent synaptic remodeling. Hear from Cheadle about his use of multiplexed mRNA detection in situ with spatial resolution to reveal temporally coordinated, experience-dependent expression of TWEAK in microglia and Fn14 in excitatory neurons, suggesting that experience regulates circuit development by initiating complementary transcriptional programs in neuronal and non-neuronal cells. This webinar is sponsored by Advanced Cell Diagnostics.

Learning Objectives:

Topics to be covered:

  • Single-cell transcriptomics and in situ validation of sensory-driven gene expression
  • Sensory experience-dependent refinement of neural circuits by transcriptional control in activated neurons
  • Induction of TWEAK expression in microglia by sensory stimulation

Watch the on-demand webinar here 

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