Elucidating tumor heterogeneity in prostate cancer by combined IHC & RNA ISH
Nallasivam Palanisamy, PhD
Associate Scientist Department of Urology Henry Ford Health System, Detroit, MI
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Outline:

Assessment of molecular heterogeneity in tumors is a challenging task. Palanisamy et al have demonstrated the novel existence of a rare subset of prostate cancer with heterogeneous molecular aberrations involving ETS family genes and SPINK1 expression utilizing both standard immunohistochemistry (IHC) and RNA in situ hybridization (Advanced Cell Diagnostics RNAscope® Technology). The presenter will discuss the application of RNA ISH technology to reveal previously unidentified molecular subtypes of prostate cancer.

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