ACD’s RNAscope® Technology Achieves 300-publication Milestone
October 06, 2015

ACD’s RNAscope® Technology Achieves 300-publication Milestone

Use of next generation RNA In Situ Hybridization across a diverse array of applications

HAYWARD, CALIFORNIA, October 6, 2015: Advanced Cell Diagnostics Inc. (ACD), a technology and market leader in the field of molecular pathology and developer of cell and tissue-based RNA analysis tools, is celebrating a significant milestone. Over 300 peer-reviewed research papers have now been published that feature ACD’s RNAscope technology as a core part of the research methodology, reflecting its facility in advancing the latest biological research in both academia and industry.

RNA in situ hybridization (ISH) is a valuable tool for studying spatial and cell-specific gene expression, while preserving tissue architecture. ACD’s RNAscope represents a breakthrough advance in RNA ISH, implementing a proprietary signal amplification system to enhance both sensitivity and specificity, producing a high-performance assay that is also quick and easy to use. As awareness has spread of how RNAscope ISH can accelerate a variety of studies, its rise in uptake has translated to a rapid increase in published research. Thus far in 2015, the number of new publications has already exceeded 150, more than the total number of publications from all the previous years combined, signaling acceleration in technology adoption.

Media Release

Chief Scientific Officer, Dr. Xiao-Jun Ma, commented: “This rapid increase in publications speaks directly to the value of RNAscope technology in many fields of research. Spatially mapped single-cell gene expression data are crucial to understanding the development, structure and function of complex tissues at the molecular and cellular level. However, obtaining such data has been a huge bottleneck due to technical difficulties of traditional RNA ISH methods and the loss of contextual information with grind-and-bind assays. With RNAscope, such data can be generated within weeks from a concept to publication quality images.”

The papers range from basic research in developmental biology, neuroscience, stem cells and ophthalmology, to translational research and diagnostic development of biomarkers in cancer and infectious diseases, in respected journals such as Nature, Science, Cell, New England Journal of Medicine, PNAS, PLoS One, and Clinical Cancer Research. 

Browse ACD’s publication database online. For further information, you can also visit


About Advanced Cell Diagnostics

Advanced Cell Diagnostics, Inc. (ACD) is a leader in the field of molecular pathology, developing cell and tissue‐based diagnostic tests for personalized medicine. The company’s products and services are based on its proprietary RNAscope® technology, the first automated multiplex chromogenic and fluorescent in situ hybridization platform capable of detecting and quantifying RNA biomarkers in situ at single‐molecule sensitivity. RNAscope assays are currently used by thousands of customers, including all of the global top 10 pharmaceutical companies, world leading academic institutions and many cutting edge biotechnology companies to validate biomarkers for the management of cancer and other diseases.  ACD’s industrial partnerships provide the foundation for ACD to develop companion diagnostic tests in conjunction with partners’ targeted therapeutics. ACD also pursues internal programs to develop and commercialize proprietary diagnostic tests in cancer management. Learn more about ACD and RNAscope technology at

Contact Us

Complete one of the two forms below and we will get back to you.

Advanced Cell Diagnostics

Our new headquarters office starting May 2016:

7707 Gateway Blvd.  
Newark, CA 94560
Toll Free: 1 (877) 576-3636
Phone: (510) 576-8800
Fax: (510) 576-8798


Advanced Cell Diagnostics , S.r.l.

Via Calabria15
20090 Segrate (Milano) - Italy

Phone: +39.02.95360323
Fax: +39.02.95360992
For European orders:

Advanced Cell Diagnostics China

Building 15, No. 26 Xihuan South Road
Beijing Economic-Technological Development Area
Beijing, China, Zip code: 100176

For general information: Leon Li

For general information:
For place an order:
For product support:
For career opportunities: