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Learn how to visualize and quantify any gene, in any species, in any tissue down to the single-cell level with RNAscope® ISH. Request or register for a free seminar presented by RNAscope® expert.

  • Nov
    28
    CAR-T Cell Target Selection Using Innovative in Situ Hybridization Technology
    CAR-T Cell Target Selection Using Innovative in Situ Hybridization Technology
    James Rottman
    Senior Director of Translational Development Bluebird Bio
    Courtney Anderson
    Group Leader Applications Advanced Cell Diagnostics
    Outline:

    Chimeric antigen receptor T (CAR-T) cells are promising treatments for hematologic and solid malignancies. CAR-T cells can recognize and eliminate neoplastic cells expressing specific protein antigens. However, the current generation of CAR-T cells cannot distinguish between neoplastic and normal cells that may also be expressing the same antigen, thus potentially resulting in “on-target/off-tumor” toxicity. In this GEN webinar, we will review the RNAscope hybridization (ISH) method and show applications of the technology in the CAR-T cell and immuno-oncology fields. We will demonstrate how RNAscope ISH can be utilized to identify novel CAR-T cell targets and subsequently qualify monoclonal antibodies directed against those targets for immunohistochemistry. We will show how ISH can be used to predict CAR-T cell target organ toxicity in preclinical models. Finally, we will discuss optimal preparation of tissues, cell pellets, and cytospin slides for evaluation by ISH.

    You will learn:

    - How RNAscope ISH technology can streamline your target identification and selection workflows

    - The advantages of using ISH for immunotherapeutic target cell selection

    - How ISH evaluation of target expression in normal tissues can be used to predict CAR-T cell induced toxicity

    - Optimal tissue, cell pellet, and cytospin slide preparation for RNAscope ISH

     

    Dates and Registration:
    November
    28
    Register Now
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